Cytotoxic Effects of Essential Oils and Extracts of some Mentha species on Vero, Hela and Hep2 Cell Lines

نویسندگان

  • Ajani, Y Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR
  • Bagheri, O Molecular Biotechnology Research Center, Baqiatalah University of Medical Sciences
  • Hajimehdipoor, H Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences
  • Hedayati, MH Department of Biotechnology, Pasture Institute of Iran
  • Pishehvar, H Department of Microbiology, Pharmaceutical Sciences Branch, Islamic Azad University
  • Rahimifard, N Department of Microbiology, Food and Drug Laboratory Research Center (FDLRC), MOH & ME
چکیده مقاله:

Background: Mentha species are widely used in traditional medicine mostly as anti-flatulence. Nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. Moreover, cytotoxic effects of some Mentha species have been reported. Objective: In this study, cytotoxic properties of Mentha piperita, M. spicata, M. aquatica, M. crispa, M. pulegium and M. longifolia have been investigated. Methods: Different concentrations of essential oils and total extracts of six Mentha species were tested by MTT assay against Vero, Hep2 and Hela cell lines. Results: The results showed that all samples were toxic against Vero, Hela and Hep2 cell lines (IC50 28.1-166.2 µg/ml). Conclusion: All examined Mentha species extracts and essential oils have cytotoxic effects but some of them could be considered as potent toxic agents.

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cytotoxic effects of essential oils and extracts of some mentha species on vero, hela and hep2 cell lines

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عنوان ژورنال

دوره 3  شماره 35

صفحات  88- 92

تاریخ انتشار 2010-10

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